Darkness descends with two Rabs

نویسنده

  • Michael S. Marks
چکیده

Over 60 distinct Rab GTPases regulate specific vesicular transport steps in the mammalian central vacuolar system. Wasmeier et al. (this issue, p. 271) reveal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specific lysosome-related organelle, the melanosome.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Locally Inner Automorphisms of Operator Algebras

In this paper an automorphism of a unital C-algebra is said to be locally inner if on any element it agrees with some inner automorphism. We make a fairly complete study of local innerness in von Neumann algebras, incorporating comparison with the pointwise innerness of Haagerup-Størmer. On some von Neumann algebras, including all with separable predual, a locally inner automorphism must be inn...

متن کامل

Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p.

Rab GTPases are crucial regulators of organelle biogenesis, maintenance, and transport. Multiple Rabs are expressed in all cells, and each is localized to a distinct set of organelles, but little is known regarding the mechanisms by which Rabs are targeted to their resident organelles. Integral membrane proteins have been postulated to serve as receptors that recruit Rabs from the cytosol in a ...

متن کامل

Virtual Reality Exposure Therapy for the Treatment of Darkness Phobia

Virtual reality (VR) exposure therapy is a common treatment for phobia and the efficacy of this technique has proved. The darkness phobia is one of the most common disorders among the children. This is the first research about the darkness phobia and using VR to treat the patients. The VR system designed in this article is composed from two parts: Mechatronic devices and graphics unit. As a chi...

متن کامل

Effect of explants type, light and polysaccharides on micropropagation of Catasetum orchid (Catasetum fimbriatum, L.)

The aim of present study was to investigate the effect of explants types, in light and darkness condition on propagation of lateral plantlets and also to investigate the effect of type and concentrations of carbohydrates on the regeneration of Catasetum orchid plantlets in two experiments. First experiment for propagation of lateral plantlets was done with two types of explants, shoot tips and ...

متن کامل

Comprehensive Analysis Reveals Dynamic and Evolutionary Plasticity of Rab GTPases and Membrane Traffic in Tetrahymena thermophila

Cellular sophistication is not exclusive to multicellular organisms, and unicellular eukaryotes can resemble differentiated animal cells in their complex network of membrane-bound structures. These comparisons can be illuminated by genome-wide surveys of key gene families. We report a systematic analysis of Rabs in a complex unicellular Ciliate, including gene prediction and phylogenetic cluste...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of Cell Biology

دوره 175  شماره 

صفحات  -

تاریخ انتشار 2006